List of 421 Major News Events in History, Most Important Historical Events in 421
| Date | Event |
|---|---|
| February 8, 421 | Constantius III becomes co-Emperor of the Western Roman Empire. |
| March 25, 421 | Italian city Venice is founded with the dedication of the first church, that of San Giacomo di Rialto on the islet of Rialto. |
| June 7, 421 | Emperor Theodosius II marries Aelia Eudocia at Constantinople (Byzantine Empire). |