List of 1621 Major News Events in History, Most Important Historical Events in 1621
| Date | Event |
|---|---|
| February 9, 1621 | Gregory XV becomes Pope, the last Pope elected by acclamation. |
| February 17, 1621 | Myles Standish is appointed as first military commander of the English Plymouth Colony in North America. |
| March 16, 1621 | Samoset, a Mohegan, visits the settlers of Plymouth Colony and greets them, "Welcome, Englishmen! My name is Samoset." |
| March 22, 1621 | The Pilgrims of Plymouth Colony sign a peace treaty with Massasoit of the Wampanoags. |
| April 5, 1621 | The Mayflower sets sail from Plymouth, Massachusetts on a return trip to England. |
| May 24, 1621 | The Protestant Union is formally dissolved. |
| June 3, 1621 | The Dutch West India Company receives a charter for New Netherland. |
| June 21, 1621 | Execution of 27 Czech noblemen on the Old Town Square in Prague as a consequence of the Battle of White Mountain. |
| October 29, 1621 | The London Pageant of 1621 celebrates the inauguration of Edward Barkham (Lord Mayor). |