List of 1581 Major News Events in History, Most Important Historical Events in 1581
| Date | Event |
|---|---|
| April 4, 1581 | Francis Drake is knighted by Queen Elizabeth I for completing a circumnavigation of the world. |
| July 26, 1581 | Plakkaat van Verlatinghe (Act of Abjuration): The northern Low Countries declare their independence from the Spanish king, Philip II. |