List of 1561 Major News Events in History, Most Important Historical Events in 1561
| Date | Event |
|---|---|
| April 14, 1561 | A celestial phenomenon is reported over Nuremberg, described as an aerial battle. |
| June 4, 1561 | The steeple of St Paul's, the medieval cathedral of London, is destroyed in a fire caused by lightning and is never rebuilt. |
| July 2, 1561 | Menas, emperor of Ethiopia, defeats a revolt in Emfraz. |
| August 19, 1561 | Mary, Queen of Scots, aged 18, returns to Scotland after spending 13 years in France. |
| August 24, 1561 | Willem of Orange marries duchess Anna of Saxony. |
| September 2, 1561 | Entry of Mary, Queen of Scots into Edinburgh, a spectacular civic celebration for the Queen of Scotland, marred by religious controversy. |
| September 9, 1561 | The ultimately unsuccessful Colloquy of Poissy opens in an effort to reconcile French Catholics and Protestants. |
| September 10, 1561 | Fourth Battle of Kawanakajima: Takeda Shingen defeats Uesugi Kenshin in the climax of their ongoing conflicts. |
| September 23, 1561 | King Philip II of Spain issues cedula, ordering a halt to colonizing efforts in Florida. |
| October 18, 1561 | In Japan the fourth Battle of Kawanakajima is fought between the forces of Uesugi Kenshin and Takeda Shingen, resulting in a draw. |