List of 1540 Major News Events in History, Most Important Historical Events in 1540
| Date | Event |
|---|---|
| January 6, 1540 | King Henry VIII of England marries Anne of Cleves. |
| March 23, 1540 | Waltham Abbey is surrendered to King Henry VIII of England; the last religious community to be closed during the Dissolution of the Monasteries. |
| May 9, 1540 | Hernando de Alarcón sets sail on an expedition to the Gulf of California. |
| June 24, 1540 | English King Henry VIII commands his fourth wife, Anne of Cleves, to leave the court. |
| July 9, 1540 | King Henry VIII of England annuls his marriage to his fourth wife, Anne of Cleves. |
| July 28, 1540 | Henry VIII of England marries his fifth wife, Catherine Howard, on the same day his former Chancellor, Thomas Cromwell, is executed on charges of treason. |
| August 15, 1540 | Arequipa, Peru is founded. |
| September 27, 1540 | The Society of Jesus (Jesuits) receives its charter from Pope Paul III. |
| October 18, 1540 | Spanish conquistador Hernando de Soto's forces destroy the fortified town of Mabila in present-day Alabama, killing Tuskaloosa. |