List of 1538 Major News Events in History, Most Important Historical Events in 1538
| Date | Event |
|---|---|
| February 24, 1538 | Treaty of Nagyvárad between Holy Roman Emperor Ferdinand I and King John Zápolya of Hungary and Croatia. |
| May 26, 1538 | Geneva expels John Calvin and his followers from the city. Calvin lives in exile in Strasbourg for the next three years. |
| July 25, 1538 | The city of Guayaquil is founded by the Spanish Conquistador Francisco de Orellana and given the name Muy Noble y Muy Leal Ciudad de Santiago de Guayaquil. |
| August 6, 1538 | Bogotá, Colombia, is founded by Gonzalo Jiménez de Quesada. |
| September 28, 1538 | Ottoman–Venetian War: The Ottoman Navy scores a decisive victory over a Holy League fleet in the Battle of Preveza. |
| October 28, 1538 | The Universidad Santo Tomás de Aquino is founded in what is now the Dominican Republic. |
| December 17, 1538 | Pope Paul III excommunicates Henry VIII of England. |