List of 1527 Major News Events in History, Most Important Historical Events in 1527
| Date | Event | 
|---|---|
| January 1, 1527 | Croatian nobles elect Ferdinand I, Archduke of Austria as King of Croatia in the 1527 election in Cetin. | 
| February 24, 1527 | Coronation of Ferdinand I as the king of Bohemia in Prague. | 
| May 6, 1527 | Spanish and German troops sack Rome; many scholars consider this the end of the Renaissance. | 
| May 16, 1527 | The Florentines drive out the Medici for a second time and Florence re-establishes itself as a republic. | 
| May 17, 1527 | Pánfilo de Narváez departs Spain to explore Florida with 600 men | 
| June 22, 1527 | Fatahillah expels Portuguese forces from Sunda Kelapa, now regarded as the foundation of Jakarta. | 
| July 12, 1527 | Lê Cung Hoàng ceded the throne to Mạc Đăng Dung, ending the Lê dynasty and starting the Mạc dynasty. | 
| August 3, 1527 | The first known letter from North America is sent by John Rut while at St. John's, Newfoundland. |