List of 1506 Major News Events in History, Most Important Historical Events in 1506
| Date | Event |
|---|---|
| January 22, 1506 | The first contingent of 150 Swiss Guards arrives at the Vatican. |
| April 18, 1506 | The cornerstone of the current St. Peter's Basilica is laid. |
| April 19, 1506 | The Lisbon Massacre begins, in which accused Jews are slaughtered by Portuguese Catholics. |
| April 21, 1506 | The three-day Lisbon Massacre comes to an end with the slaughter of over 1,900 suspected Jews by Portuguese Catholics. |
| August 5, 1506 | The Grand Duchy of Lithuania defeats the Crimean Khanate in the Battle of Kletsk. |